Jianghong Rao Lab In the Departments of Radiology and Chemistry

Youngpil Kim, Ph.D.



Youngpil Kim, Ph.D.

Molecular Imaging Program at Stanford
Dept. of Radiology
Stanford School of Medicine
Lucas Expansion, P089
1201 Welch Road
Stanford, CA 94305-5484

E-mail: ypkim@stanford.edu

Youngpil prefers to be called "Pil."

Research Project

In vitro and in vivo detection of cancer-related enzyme activity using nanoparticles, and BRET-based detection of post-translationally modifying enzymes.

I am focusing on development of nanoprobes to detect disease biomarkers in vitro and in vivo with high sensitivity and specificity, especially based on bioluminescence or bioluminescence resonance energy transfer (BRET). By combining nanoparticles with specific biomolecules, the application will be extended to many biological fields including cancer diagnosis, molecular imaging, and multiplex targeting.

Personal Websites

http://www.wix.com/pilest/ypkim
http://blog.naver.com/pilest(in Korean)

Education

Ph.D. Dept. of Biological Sciences, KAIST, Korea (2004-2008)
M.Sc. Dept. of Life Science, Hanyang Univ. Korea (2000)
B.Sc. Dept. of Biology, Hanyang Univ. Korea (1996)

Experience

Postdoc Fellow, Dept. of Radiology Stanford Univ. (12. 2008-present)
Postdoc Fellow, Dept. of Biological Sciences, KAIST, Korea (1. 2008-12. 2008)
Team Leader in KoreaBiosystems Co. Ltd. (2000-2003) (founded in KIST, Korea)

Selected Publications (22 total)

10. Y.-P. Kim, S. Park, E. Oh, Y.-H. Oh, and H.-S. Kim. On-Chip Detection of Protein Glycosylation Based on Energy Transfer between Nanoparticles. Biosens. Bioelectron. 2009. 24, 1189.
9. Y.-P. Kim, Y.-H. Oh, E. Oh, S. Ko, M.-K. Han, and H.-S. Kim. Energy Transfer-Based Multiplexed Assay of Proteases by Using Gold Nanoparticle and Quantum Dot Conjugates on a Surface. 2008. Anal. Chem. 80(12), 4634.
8. Y.-P. Kim, B. S. Lee, E. Kim, I. S. Choi, D. W. Moon, T. G. Lee, and H.-S. Kim. Activity-Based Assay of Matrix Metalloproteinase on Nonbiofouling Surfaces Using Time-of-Flight Secondary-Ion Mass Spectrometry. 2008. Anal. Chem. 80(13), 5094.
7. Y.-P. Kim, Y.-H. Oh, and H.-S. Kim. Protein Kinase Assay on Peptide-Conjugated Gold Nanoparticles. 2008. Biosens. Bioelectron. 23(7), 980.
6. Y.-P. Kim, K. Cho, D. Lee, Y. Piao, Y. H. Ahn, J. S. Yoo, T. Hyun and H.-S. Kim. Efficient Enrichment and Desalting of Protein Digests Using Magnetic Mesocellular Carbon Foams in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. 2007. Rapid Commun. Mass Spectrom. 21(21), 3435
5. Y.-P. Kim, E. Oh, Y.-H. Oh, D. W. Moon, T. G. Lee, and H.-S. Kim. Protein Kinase Assay on Peptide-Conjugated Gold Nanoparticles by Using Secondary-Ion Mass Spectrometric Imaging. 2007. Angew. Chem. Int. Ed. 46(36), 6816.
4. Y.-P. Kim, M.-Y. Hong, J. Kim, E. Oh, H. K. Shon, D. W. Moon, H.-S. Kim, and T. G. Lee. Quantitative Analysis of Surface-Immobilized Protein by TOF-SIMS: Effects of Protein Orientation and Trehalose Additive. 2007. Anal. Chem. 79(4) 1377.
3. E. Oh, D. Lee, Y.-P. Kim, S. Y. Cha, D.-B. Oh, H. A. Kang, J. Kim, and H.-S. Kim. Nanoparticle-based Energy Transfer for a Rapid and Simple Detection of Protein Glycosylation. 2006. Angew. Chem. Int. Ed. 45(47), 7959.
2. Y.-P. Kim, E. Oh, M.-Y. Hong, D. Lee, M.-K. Han, H. K. Shon, D. W. Moon, H.-S. Kim, and T. G. Lee. Gold nanoparticle-enhanced secondary ion mass spectrometry imaging of peptides on self-assembled monolayers. 2006. Anal. Chem. 78(6), 1913.
1. J. Lee, D. Lee, E. Oh, J. Kim, Y.-P. Kim, S. Jin, H.-S. Kim, Y. H., J. H. Kwak, J.-G. Park, C.-H. Shin, J. Kim, and T. Hyeon. Preparation of a magnetically switchable bioelectrocatalytic system employing cross-linked enzyme aggregates in magnetic mesocellular carbon foam. 2005. Angew. Chem. Int. Ed. 44(45), 7427.

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