Jianghong Rao Lab In the Departments of Radiology and Chemistry

Jinghang Xie, Ph.D.

Jinghang Xie, Ph.D.

Jinghang did his PhD with Dr. William K. Chan at University of the Pacific, where he discovered that the flanking sequences of dioxin response elements (DRE) contribute to the differential regulation of Cytochrome P450 enzyme 1A1 and 1B1. He has also constructed Pichia Pastoris expression systems to over express full length human Ah receptor and Arnt proteins. In current research, Jinghang mainly focus on the biological evaluation of novel molecular probes for the diagnosis of cancer and infectious diseases.

Ph.D. in Pharmaceutical and Chemical Sciences/Molecular Pharmacology 2014
Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific

M.S. in Microbiology and Biochemical Pharmacy 2009
School of Life Science and Technology, China Pharmaceutical University

B.E. in Life Sciences and Biotechnologies 2007
China Pharmaceutical University

Recent publications

Zheng, Y.*, Xie, J.*, Huang, X., Dong, J., Park, M. S., Chan, W. K. (2016) Binding studies using Pichia pastoris expressed human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins Protein Expression and Purification, 122: 72-81 (* contributed equally)

Sravan, P. C., Miller, M. R., Pal, A., Dong, J., Madadi, N. R., Xie, J., Joo, H., Tsai, J., Batoon, P., Samoshin, V., Franz, A., Cox, T., Miles, J., Chan, W. K., Park, M. S., Alhamadsheh, M. M. (2015) A biomimetic approach for enhancing the in vivo half-life of peptides Nature Chemical Biology, 11:793-8

Lyu, F., Xu, M., Cheng, Y., Xie, J., Rao, J., Tang, S. K. (2015) Quantitative detection of cells expressing BlaC using droplet-based microfluidics for use in the diagnosis of tuberculosis Biomicrofluidics, 9 (4): 044120

Xie J., Huang X., Pham H.M., Park M.S., and Chan, W.K. (2014) Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule. Biochemical Pharmacology. 88:253-65

Park M. S., Chu F., Xie J., Wang Y, Bhattacharya P. and Chan W. K. (2011) Identification of cyclophilin-40 interacting proteins reveals potential cellular function of cyclophilin-40, Analytical Biochemistry. 410:257-65

Zou J., Wang S., Yang J., Luo X., Xie J., and Xi T. (2009) Knockdown of SMYD3 by RNA interference down-regulates c-Met expression and inhibits cells migration and invasion induced by HGF. Cancer Letters. 280:78-85

Tang C., Lu Y., Xie J., Wang F., Zou J., Yang J., Xing Y., and Xi T. (2009) Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anti-Cancer Drugs. 20:249-58

Xie, J., Gu, J. (2007) Progress on new antibiotics development by activation of silent genes World Notes on Antibiotics. 28 (4): 178-81

Patents

Jianghong Rao, Yunfeng Cheng, Jinghang Xie. "United States Patent 62/203,635 Probes for rapid and specific detection of mycobacteria", Leland Stanford Junior University, Aug 11, 2015

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