Jianghong Rao Lab In the Departments of Radiology and Chemistry

Hexin Xie, Ph.D.

Hexin Xie, Ph.D.

Hexin is working on beta-lactamases-based fluorogenic probes and their applications in rapid detection of diseases.


Ph.D. in Synthetic Organic Chemistry, 2003- 2008
Department of chemistry and chemical biology, the University of New Mexico, Albuquerque, USA
Advisor: Professor Dr. Wei Wang
Thesis title : Development of Organocatalytic reactions: an efficient approach for C-C bond formation


    1. Xie, H., Zhang, S., Li, H., Zhang, X., Zhao, S., Xu, Z., Song, X., Yu, X. and Wang, W. Total Synthesis of Polyene Natural Product Dihydroxerulin by Mild Organocatalyzed Dehydrogenation of Alcohols. Chem. Eur. J.,2012, 18, 2230.

    2. Zhan, K., Xie, H., Gall, J., Ma, M.-L., Griesbeck, O., Salehi, A. and Rao, J. Real-Time Imaging of Rab5 Activity Using a Prequenched Biosensor. ACS Chem. Biol, 2011, 6, 692.

    3. Xie, H., Zhang, Y., Zhang, S., Chen, X., Wang, W. Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083. Angew. Chem. Int. Ed., 2011,50,11773.

    4. Zhang, S.-L.*, Xie, H.*, Zhu, J., Li, H., Zhang, X.-S., Li, J. and Wang, W. Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions. Nat. Commun. 2011, 2, 1214/1. *Co-first author

    5. Xie, H., Zu, L., Oueis, H. R., Li, H., Wang, J. and Wang, W. Proline-Catalyzed Direct Inverse Electron Demand Diels-Alder Reactions of Ketones with 1,2,4,5-Tetrazines. Org. Lett., 2008, 10, 1923.

    6. Wang, J., Xie, H., Li, H., Zu, L. and Wang, W. A highly stereoselective hydrogen-bond-mediated Michael-Michael cascade process through dynamic kinetic resolution. Angew. Chem. Int. Ed., 2008, 47, 4177.

    7. Xie, H., Zu, L., Li, H., Wang, J. and Wang, W. Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions: Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes. J. Am. Chem. Soc., 2007, 129, 10886.

    8. Wang, J., Li, H., Xie, H., Zu, L., Shen, X. and Wang, W. Organocatalytic enantioselective cascade Michael-Aldol condensation reactions: efficient assembly of densely functionalized chiral cyclopentenes. Angew. Chem. Int. Ed., 2007, 46, 9050.

    9. Ma, S. and Xie, H. Study on halolactamization-g-hydroxylation or haloimino-lactonization of 2,3-alkadienamides. Tetrahedron, 2005, 61, 251.

    10. Ma, S. and Xie, H. Steric Hindrance-Controlled Pd(0)-Catalyzed Coupling-Cyclization of 2,3-Allenamides and Organic Iodides. An Efficient Synthesis of Iminolactones and g-Hydroxy-g -lactams. J. Org. Chem., 2002, 67, 6575.

    11. Ma, S., Xie, H., Wang, G., Zhang, J., and Shi, Z. Hydrohalogenation reaction of substituted 1,2-allenic carboxylic acids, esters, amides, nitriles, and diphenyl phosphine oxides. Synthesis, 2001, 5, 713.

    12. Ma, S. and Xie, H. Unexpected Facile Sequential Halolactamization-Hydroxylation of 2,3-Allenamides with CuX2 for the Efficient Synthesis of 4-Halo-5-hydroxypyrrol- 2(5H)-ones. Org. Lett., 2000, 2, 3801.

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