Jianghong Rao Lab In the Departments of Radiology and Chemistry

Brandon-Luke L. Seagle



Brandon-Luke L. Seagle

Medical Scientist (MD/PhD) Training Program, Stanford University School of Medicine
PhD Candidate, Interdisciplinary Program in Biophysics, Stanford University School of Medicine

I am currently rotating in the Rao lab.

Education:

--Medical Scientist Training Program, Stanford University, 2006-current
--Biological Chemistry (BS with honors) and Chemistry (BA), University of Chicago, 2006

Research:

--James R. Norris, Jr. lab, Chemistry Department, University of Chicago, 12/2002-06/2006 (biophysical chemistry lab)

Publications:

7. E. M. Gasyna, B. L. Seagle, Z. L. Gasyna, J. R. Norris Jr., W. F. Mieler. Photoprotection of RPE cells by Melanin against Blue Light-Induced Apoptosis: Evidence of Melanogenesis in Cultured RPE Cells. Submitted.
6. K. A. Rezai, E. M. Gasyna, B. L. Seagle, J. R. Norris Jr., K. A. Rezaei. AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium cells. Graefeís Arch. Clin. Exp. Ophthalmol. 2008, 246 (5), 671-676.
5. B. L. Seagle, E. M. Gasyna, W. F. Mieler, and J. R. Norris Jr. Photoprotection of Human RPE Cells against Blue Light-induced Apoptosis by Melanin Free Radicals from Sepia officinalis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103 (45), 16644-16648.
4. B. L. Seagle, K. A. Rezai, E. M. Gasyna, Y. Kobori, K. A. Rezaei, and J. R. Norris Jr. Time-resolved detection of melanin free radicals quenching reactive oxygen species. J. Amer. Chem. Soc. 2005, 127, 11220-11221.
3. B. L. Seagle, K. A. Rezai, Y. Kobori, E. M. Gasyna, K. A. Rezaei, and J. R. Norris Jr. Melanin photoprotection in the human retinal pigment epithelium and its correlation with light-induced cell apoptosis. Proc. Natl. Acad. Sci. U.S.A. 2005, 102 (25), 8978-8983.
2. R. H. Baxter, B. L. Seagle, N. Ponomarenko, and J. R. Norris Jr. Cryogenic structure of the photosynthetic reaction center of Blastochloris viridis in the light and dark. Acta Cryst. 2005, D61, 605-612.
1. R. H. Baxter, B. L. Seagle, N. Ponomarenko, and J. R. Norris Jr. Specific radiation damage illustrates light-induced structural changes in the photosynthetic reaction center. J. Amer. Chem. Soc. 2004, 126, 16728-16729.

Grants:

--NIH Medical Scientist Training Grant at Stanford Medical School, 2006-current
--Howard Hughes Medical Institute Undergraduate Research Fellowship, summer 2005
--Richter grants for undergraduate research, two awards, summers 2003 and 2004

Awards:

--Norman H. Nachtrieb Memorial Award for Excellence in Undergraduate Studies of Chemistry, University of Chicago Chemistry Department, 2006
--Selected as a best presenter at the HHMI undergraduate research program lectures, 2005
--Deanís list, 2002-2006
--Watson-Brown Foundation Scholarship, 2002-2006

Teaching (HS: high school program, U: undergraduate course, G: graduate course):

Stanford University:
--TA for Practice of Medicine, Emergency Medicine, Fall-Spring 2008-09 G
--Head TA for Stanford Medical Youth Science Program, Summers 2007 & 2008 HS
--TA for Center for Clinical Immunology research internship program, Summer 2007 HS
--TA for Introduction to Medicine, Spring 2007 G
--TA for Human Physiology, Winter 2007 U
University of Chicago:
--TA for Honors Organic Chemistry course and laboratory, 09/2005-03/2006 (2 quarters) U
--TA for Organic Chemistry course and laboratory, Summer 2005 (1 quarter) U
--TA for Biochemistry course and laboratory, 09/2004-06/2006 (7 quarters) U
--TA for Core Biology course and laboratory, 01/2004-12/2004 (3 quarters) U
--Tutor for Neighborhood Schools Program, 10/2002-03/2004 HS

Talks and Presentations:

--Melanin Photoprotection in Human Retinal Pigment Epithelium Cells as Revealed by Time-Resolved Electron Paramagnetic Resonance Spectroscopy (Abstract and Poster) Association for Research in Vision and Ophthalmology Annual Conference, Ft. Lauderdale, FL 2006
--Melanin free radicals scavenge reactive oxygen species and prevent RPE light-induced apoptosis. (Lecture) University of Chicago, HHMI undergraduate research lectures. 08/10/2005
--Melanin photochemistry (Poster) Northwestern University, Chicago Area Undergraduate Research Symposium. 04/23/2005

Community Service:

--Physician assistant volunteer, Pacific Free Clinic, 2006-2007
--University of Chicago American Red Cross Vice President, 06/2005-06/2006
--University of Chicago American Red Cross Blood Services Director, 09/2004-06/2005
--Neighborhood School Program, 10/2002-03/2004
--Informal but active and regular mentorship to numerous disadvantaged high school students applying to colleges and to several college students, mostly at Stanford and UChicago, applying to medical schools.

Hobbies/Interests/Part-time Employment:

--Private tutoring
--Mentorship, professional advising and academic admission counseling
--Language study: Mandarin, Korean
--Entrepreneurship and leadership and professional development
--Marathons, cycling, climbing, weight training, hiking
--New laproscopic surgical instrument evaluation at Intuitive Surgical, Inc., 2007-08

Stanford Medicine Resources:

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