Jianghong Rao Lab In the Departments of Radiology and Chemistry

Mikael Palner, Ph.D.



Mikael Palner, Ph.D.

Mikael really like images, good shiny images which give another dimension to science. To achieve this, he focuses his research on evaluating new potential biomarkers for imaging; fluorescent, radioactive or magnetic markers which can be quantitatively measured in the living being.

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Education:

Postdoc: Bionanotechnology and Nanomedicine Laboratory, at University
of Copenhagen, Denmark
PhD: Center for Integrated Molecular Brain Imaging, University
of Copenhagen, Denmark
MSc: Bioengeneering at Denmarks Technical University, Denmark
BSc: Organic Chemistry at Denmarks Technical University, Denmark

Publications:

    1. Bin Shen*, Jongho Jeon*, Mikael Palner, Deju Ye, Adam Shuhendler, Frederick T. Chin and Jianghong Rao (*: co-first authors), “Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-3 Triggered Nanoaggregation Probe”, Angew. Chem. Int. Ed. 2013, 52, In-press. (Selected as a cover picture) (DOI: 10.1002/anie.201303422)
    2. Ettrup, A., Mikkelsen, J. D., Lehel. S., Madsen, J., Nielsen, E. Ø., Palner, M., Timmermann, D. B., Peters, D., Knudsen, G. M. (2011) 11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. J Nucl Med. 52(9), 1449-5
    3. Ettrup, A., Hansen, M., Santini, M. A., Paine, J., Gillings, N., Palner, M., Lehel, S., Herth, M. M., Madsen, J., Kristensen, J., Begtrup, M., Knudsen, G. M. (2011) Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers. Eur J Nucl Med Mol Imaging, 38(4), 681-9
    4. Palner, M., Kjaerby, C., Knudsen, G. M., Cumming, P. (2011) Effects of unilateral 6-OHDA lesion on [3H]NPA binding in striatum ex vivo, and vulnerability to amphetamine-evoked dopamine release in rat. Neurochem Int, 58(3), 243-7
    5. Palner, M., Underwood, M. D., Kumar, D. J. S., Arango, V., Knudsen, G. M., Mann, J. J., Parsey R. V. (2011). Ex vivo evaluation of the serotonin 1A receptor partial agonist [(3)H]CUMI-101 in awake rats. Synapse 65(8):715-23
    6. Ettrup, A., Palner, M., Gillings, N., Santini, M. A., Hansen, M., Kornum, B. R., Rasmussen, L. K., Någren, K., Madsen, J., Begtrup, M., Knudsen, G. M. (2010). Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. Journal of nuclear medicine : 51(11), 1763-70
    7. Palner, M., McCormick, P., Gillings, N., Begtrup, M., Wilson, A. A., Knudsen, G. M. (2010). Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine. Nuclear medicine and biology, 37(1), 35-40.
    8. Palner, M., McCormick, P., Parkes, J., Knudsen, G. M., Wilson, A. A. (2010). Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957☆. Nuclear Medicine and Biology, 37(7), 837-843..
    9. Prabhakaran, J., Majo, V. J., Milak, M. S., Kassir, S., Palner, M., Savenkova, L., Mali, P., Arango, V., Mann, J. J., Parsey, R. V., Kumar, J. S. D. (2010). Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors. Bioorganic & medicinal chemistry letters, 20(12), 3499-501.
    10. Kramer, V., Herth, M. M., Santini, M. A., Palner, M., Knudsen, G. M., & Rösch, F. (2010). Structural Combination of Established 5-HT Receptor Ligands: New Aspects of the Binding Mode. Chemical biology & drug design, (1), 361-366.
    11. Syvänen, S., Lindhe, O., Palner, M., Kornum, B. R., Rahman, O., Långström, B., Knudsen G. M., Hammarlund-Udenaes, M. (2009). Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport. Drug metabolism and disposition, 37(3), 635-43.
    12. Herth, M. M., Kramer, V., Piel, M., Palner, M., Riss, P. J., Knudsen, G. M., Rösch, F. (2009). Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorganic & medicinal chemistry, 17(8), 2989-3002.
    13. Herth, M. M., Debus, F., Piel, M., Palner, M., Knudsen, G. M., Lüddens, H., Rösch, F. (2008). Total synthesis and evaluation of [18F]MHMZ. Bioorganic & medicinal chemistry letters, 18(4), 1515-9.
    14. Søndergaard, K., Kristensen, J. L., Palner, M., Gillings, N., Knudsen, G. M., Roth, B. L., Begtrup, M. (2005). Synthesis and binding studies of 2-arylapomorphines. Organic & biomolecular chemistry, 3(22), 4077-81.

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