Jianghong Rao Lab In the Departments of Radiology and Chemistry

Kyung Hyun Lee, Ph.D.

Kyung Hyun Lee, Ph.D.

Kyung's research in the Rao group mainly focuses on the development of RNA aptamer-based RNA and cancer imaging systems.

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Postdoctoral training, Stanford University, Stanford, CA, USA
Advisor: Prof. Jianghong Rao

Ph.D. in Biochemistry, Korea University, Seoul, South Korea (Joint program with Korea Institute of Science & Technology)
Advisor: Prof. Jaehoon Yu and Prof. Yong Keun Park
Thesis title : “Studies of RNA aptamers selected from calsenilin and histone H3”

M.S. in Molecular Biology
Dankook University, Seoul, South Korea
Advisor: Prof. Sunjoo Jeong

B.S. in Molecular Biology
Dankook University, Seoul, South Korea


  • Jeon J*, Lee KH*, Rao J. A Strategy to Enhance the Binding Affinity of Fluorophore-Aptamer Pairs for RNA Tagging with Neomycin Conjugation, Chem Commun. 2012, 48, 10034-10036 (* Equal contribution) (DOI: 10.1039/c2cc34498j)
  • Jongho J, Shen B, Xiong L, Zheng M, Lee KH, Rao J. An Efficient Method for Site-Specific 18F-Labeling of Biomolecules Using the Rapid Condensation Reaction between 2-Cyanobenzothiazole and Cysteine, Bioconjugate Chemistry, 2012, 23, 1902-1908
  • Soonsil Hyun, Kyung Hyun Lee, Areum Han, and Jaehoon Yu. An RNA Aptamer That Selectively Recognizes Symmetric Dimethylation of Arginine 8 in the Histone H3 N-Terminal Peptide. Nucl. Acid Ther. (Formerly Oligonucleotides) 2011, 21, 157-163
  • Areum Han, Kyung Hyun Lee, Soonsil Hyun, Nam Joo Lee, Su Jin Lee, Heeyong Hwang, and Jaehoon Yu. Methylation-Mediated Control of Aurora Kinase B and Haspin with Epigenetically Modified Histone H3 N-Terminal Peptides. Bioorg. Med. Chem. 2011, 19, 2373-2377
  • Jungjoon Lee*, Kyung Hyun Lee*, Jongho Jeon*, Anca Dragulescu-Andrasi, Fei Xiao, and Jianghong Rao. Combining SELEX Screening and Rational Design to Develop Light-Up Fluorophore-RNA Aptamer Pairs for RNA Tagging. ACS Chem. Biol. 2010, 5, 1065-1074 (*; Equal contribution)
  • Kyung Hyun Lee, Nam Ju Lee, Soonsil Hyun, Yong Keun Park, Eun Gyeong Yang, Jun-Kyu Lee, Sunjoo Jeong, and Jaehoon Yu. Histone H3 N-Terminal Peptide Binds Directly to Its Own mRNA: a Possible Mode of Feedback Inhibition to Control Translation. ChemBioChem 2009, 10, 1313-1316
  • Kyung Hyun Lee, Sunjoo Jeong, Eun Gyung Yang, Yong-Keun Park, and Jaehoon Yu. An RNA Aptamer That Recognizes a Specific Conformation of the Protein Calsenilin. Bioorg. Med. Chem. 2007, 15, 7545-7552
  • Soonsil Hyun, Hyun Jin Kim, Nam Ju Lee, Kyung Hyun Lee, Yeongran Lee, Dae Ro Ahn, Keysun Kim, Sunjoo Jeong, and Jaehoon Yu. Alpha-Helical Peptide Containing N,N-Dimethyl Lysine Residues Displays Low-Nanomolar and Highly Specific Binding to RRE RNA. J. Am. Chem. Soc. 2007, 129, 4514~4515
  • Soonsil Hyun, Kyung Hyun Lee, and Jaehoon Yu. A Strategy for the Design of Selective RNA Binding Agents. Preparation and RRE RNA Binding Affinities of a Neomycin-peptide Nucleic Acid Heteroconjugate Library. Bioorg. Med. Chem. Lett. 2006, 16, 4757~4759
  • Kyung Hyun Lee, Byung Hee Shin, Kye Jung Shin, Dong Jin Kim, and Jaehoon Yu. A Hybrid Molecule That Prohibits Amyloid Fibrils and Alleviates Neuronal Toxicity Induced by beta-amyloid (1-42). Biochem. Biophys. Res. Commun. 2005, 328, 816~823
  • Jongkook Lee, Miyun Kwon, Kyung Hyun Lee, Sunjoo Jeong, Soonsil Hyun, Kye Jung Shin, and Jaehoon Yu. An Approach to Enhance Specificity against RNA Targets Using Heteroconjugates of Aminoglycosides and Chloramphenicol (or Linezolid). J. Am. Chem. Soc. 2004, 126, 1956~1957
  • Miyun Kwon, Sunjoo Jeong, Kyung Hyun Lee, Yong-Keun Park, and Jaehoon Yu. Mimicry of Tandem Repeat Peptides against Cell Surface Carbohydrates. J. Am. Chem. Soc. 2002, 124, 13996~13997

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