Our main research focus is to design, synthesize and evaluate novel molecular probes for imaging or manipulating targeted biomolecules in normal and diseased states. New projects often begin by identifying an important molecular target and then designing specific probes for that target. Next we evaluate new probes by performing cellular and in vivo imaging experiments.

We also develop novel biosensors, new strategies for early biomarker detection in biological samples, and improved methods of high throughput drug screening, and drug delivery. Our favorite targets are often enzymes that catalyze specific biochemical transformations, such as proteases, beta-lactamases, ribozymes, and kinases. More »

Our lab members contribute diverse backgrounds and expertise including synthetic and physical chemistry, protein and nanoparticle engineering, molecular and cellular biology, and many more. Each individual plays crucial roles in multiple research projects, so that our successes capitalize on effective collaborations between team members.

Our combined wealth of expertise and generous cooperation among lab members enables the rapid development of exciting and innovative projects, while providing an excellent research and training environment for Ph.D. scientists and graduate students, medical students and residents. Meet the Team »